Drug details:
Molecular formula: C₃₁H₄₈O₆

Standard name: (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

Synonyms:

Fusidine Ramycin Fusidate Fucithalmic Fucidic acid Fucidin acid Flucidin Fucidate Taksta ......

Curated SMILES: C[C@H]1[C@@H]2CC[C@]3([C@H]([C@]2(CC[C@H]1O)C)[C@@H](C[C@@H]\4[C@@]3(C[C@@H](/C4=C(/CCC=C(C)C)\C(=O)O)OC(=O)C)C)O)C

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VF: α-hemolysin
Target: Not determined
Drug effect: Reduces the virulence by down-regulating sarA and saeRS to reduce biofilm formationand α-toxin expression.
Max phase: Preclinical (in vivo)
Publication:
Liu L, et al., 2020. Subinhibitory Concentrations of Fusidic Acid May Reduce the Virulence of S. aureus by Down-Regulating sarA and saeRS to Reduce Biofilm Formation and ?-Toxin Expression. Front Microbiol 11:25.