Drug details:
Molecular formula: C₁₂H₆O₈

Standard name: 2,3,9,10-tetrahydroxypyrano[3,2-c]isochromene-6,8-dione

Synonyms:

3,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,6-dione 2,3,9,10-tetrahydroxypyrano[3,2-c]isochromene-6,8-dione Pyrano(3,2-c)(2)benzopyran-2,6-dione, 3,8,9,10-tetrahydroxy- 6,8,9,10-tetrahydroxypyrano[3,2-c][2]benzopyran-2,3-dione 6,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,3-dione Pyrano[3,2-c][2]benzopyran-2,6-dione, 3,8,9,10-tetrahydroxy- 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione Galloflavin, >=95% (HPLC) 3,8,9,10-tetrahydroxypyran[3,2-c]isochromene-2,6-quinone ......

Curated SMILES: O=C1OC2=C(C=C1O)OC(=O)C1=CC(O)=C(O)C(O)=C12

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: SapM
Drug effect: Inhibits a secreted alkaline phosphatase SapM activity to reduce intracellular mycobacterial survival in host macrophages.
Max phase: Preclinical (in vitro)
Publication:
Fernández-Soto P, et al., 2021. Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis. Sci Rep 11(1):7667.