Drug details:
Molecular formula: C₂₂H₁₉NO₃S

Standard name: (3R)-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxo-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid

Synonyms:

(3R)-8-Cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid (3R)-8-cyclopropyl-7-(1-naphthylmethyl)-5-oxo-2,3-dihydrothiazolo[3,2-a]pyridine-3-carboxylic acid

Curated SMILES: C1CC1C2=C3N([C@@H](CS3)C(=O)O)C(=O)C=C2CC4=CC=CC5=CC=CC=C54

Evidence for compound's anti-virulence activity:

Listeria
Related VF: PrfA (Pleiotropic regulatory factor)
Target: PrfA
Drug effect: Binds to PrfA, the master virulence regulator to decrease virulence factor expression.
Max phase: Preclinical (in vitro)
Publication:
Kulén M, et al., 2018. Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes. J Med Chem 61(9):4165-4175.