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16-Oxocleroda-3,13E-dien-15-oic acid

Drug details:
Molecular formula: C20H30O3

Classification: Diterpenoids; Prenol lipids; Lipids and lipid-like molecules; Organic compounds;
Synonym:  (E)-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-formylpent-2-enoic acid

Chemical structure:
Depiction based on curated SMILES CH 3 CH 3 O OH O CH 3 CH 3 H H

Evidence for compound's anti-virulence activity:

Streptococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Reduces the biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Khan AK, et al., 2017. Antibiofilm potential of 16-oxo-cleroda-3, 13(14) E-diene-15 oic acid and its five new gamma-amino gamma-lactone derivatives against methicillin resistant Staphylococcus aureus and Streptococcus mutans. Eur J Med Chem 138:480-490.








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