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2-[4-[3-(furan-2-yl)-5-phenyl-1,2-oxazol-4-yl]phenyl]quinoline-4-carboxylic acid

Drug details:
Molecular formula: C29H18N2O4

Classification: Phenylquinolines; Quinolines and derivatives; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES O N O N HO O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: NleB1
Drug effect: Inhibits the activity of Escherichia coli NleB1.
Max phase: Preclinical (in vitro)
Publication:
El Qaidi S, et al., 2018. High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors. Front Cell Infect Microbiol 8:435.

Salmonella
Related VF: TTSS (SPI-2 encode)
Target: SseK1/SseK2
Drug effect: Inhibits SseK1/SseK2 Arg glycosyltransferase activity.
Max phase: Preclinical (in vitro)
Publication:
El Qaidi S, et al., 2018. High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors. Front Cell Infect Microbiol 8:435.








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