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Compound category: Imidazoles
(total 62 related compounds in database, current show from 21 to 30)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
N-[3-(2-amino-1H-imidazol-5-yl)phenyl]adamantane-1-carboxamide;hydrochloride Depiction based on curated SMILES ClH NH 2 N H N NH O Escherichia Biofilm Preclinical (in vitro) Bunders CA, et al. 2010. Bioorg Med Chem Lett
1-[3-(2-amino-1H-imidazol-5-yl)phenyl]-3-(3,4-dichlorophenyl)urea Depiction based on curated SMILES H 2 N HN N Cl Cl NH O N H Francisella Regulation Preclinical (in vitro) Milton ME, et al. 2017. Mol Microbiol
(2Z)-2-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-7,8-dimethyl[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Depiction based on curated SMILES H 3 C OH Cl O N H 3 C CH 3 N S O Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Harmon DE, et al. 2010. Antimicrob Agents Chemother
(E)-3-(4-Acetyl-phenyl)-N-[4-(1-hydroxy-6-nitro-1H-benzoimidazol-2-yl)-phenyl]-acrylamide Depiction based on curated SMILES N + N O _ O N HO H 3 C N H O O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
(E)-3-(4-acetylphenyl)-N-(4-(6-cyano-1-hydroxy-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide Depiction based on curated SMILES HO N N N H 3 C N H O O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES HO N _ O O + N N O N H F Pseudomonas
Yersinia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vivo)		 Marsden AE, et al. 2016. Antimicrob Agents Chemother
Kim OK, et al. 2009. J Med Chem
Garrity-Ryan LK, et al. 2010. Infect Immun
2,2,2-trifluoro-N-[2-[2-(4-iodoanilino)-2-oxoethyl]sulfanyl-3H-benzimidazol-5-yl]acetamide Depiction based on curated SMILES F I NH N H F O F O HN N S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
2-(1H-benzimidazol-2-ylsulfanyl)-N-(3,4-dichlorophenyl)acetamide Depiction based on curated SMILES Cl Cl NH N H O N S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
2-(1H-benzimidazol-2-ylthio)-N-[3-(methylthio)phenyl]acetamide Depiction based on curated SMILES S N H N CH 3 O N H S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
2-(1H-benzimidazol-2-ylsulfanyl)-N-(4-bromophenyl)acetamide Depiction based on curated SMILES Br HN N H O N S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
   


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