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Compound category: Diazines
(total 31 related compounds in database, current show from 11 to 20)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
(5E)-5-({4-[(2,4-DICHLOROPHENYL)METHOXY]-3-ETHOXYPHENYL}METHYLIDENE)-1-(3,5-DIMETHYLPHENYL)-1,3-DIAZINANE-2,4,6-TRIONE Depiction based on curated SMILES H 3 C CH 3 O O Cl Cl O CH 3 O NH O N Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
(5E)-5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-1-(3,5-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione Depiction based on curated SMILES CH 3 O N H O Cl Cl O CH 3 O N Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
5-{3-[(2,4-difluorophenoxy)methyl]-4-methoxybenzylidene}-2,4,6(1H,3H,5H)-pyrimidinetrione Depiction based on curated SMILES O F F O O N H CH 3 HN O O Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
5-{4-[(2,4-dichlorobenzyl)oxy]-3-ethoxybenzylidene}pyrimidine-2,4,6(1H,3H,5H)-trione Depiction based on curated SMILES Cl Cl O O NH O H 3 C HN O O Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
2-(2-Pyridin-3-yl-vinyl)-3-m-tolyl-3H-quinazolin-4-one Depiction based on curated SMILES N O H 3 C N N Klebsiella Aerobactin Preclinical (in vitro) Bailey DC, et al. 2018. SLAS Discov
2-(3-Pyridinyl)-3-(4-methoxyphenyl)-3,4-dihydroquinazoline-4-one Depiction based on curated SMILES N O CH 3 N N O Klebsiella Aerobactin Preclinical (in vitro) Bailey DC, et al. 2018. SLAS Discov
3-(5-bromo-2-pyridyl)-2-(3-pyridyl)quinazolin-4-one Depiction based on curated SMILES Br N N N N O Klebsiella Aerobactin Preclinical (in vitro) Bailey DC, et al. 2018. SLAS Discov
N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine Depiction based on curated SMILES N S CH 3 N H N N N H H 3 C Legionella Dot/Icm (Defect in organella trafficking/intracellular multiplication) Preclinical (in vitro) Cheng E, et al. 2022. mBio
N-(2,5-dimethylphenyl)-2-(4-oxo-3(4H)-quinazolinyl)acetamide Depiction based on curated SMILES O N N CH 3 O N H CH 3 Mycobacterium Immune modulation Preclinical (in vitro) Karanja CW, et al. 2021. ACS Infect Dis
N-(2-methyl-5-nitrophenyl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide Depiction based on curated SMILES O O N N H 3 C N H _ O O + N Mycobacterium Immune modulation Preclinical (in vitro) Karanja CW, et al. 2021. ACS Infect Dis
   


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