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Compound category: Diazines
(total 31 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
N-(furan-2-ylmethylcarbamoyl)-2-(4-oxobenzo[g]quinazolin-3-yl)acetamide Depiction based on curated SMILES O N H O HN O O N N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
[2-[[(1R,2R)-2-methylcyclohexyl]carbamoylamino]-2-oxoethyl] 4-oxo-3-phenylphthalazine-1-carboxylate Depiction based on curated SMILES N N O O N H H H H 3 C O N H O O Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
ML346 Depiction based on curated SMILES O HN O N H O CH 3 O Streptococcus Adherence Preclinical (in vivo) Guan XN, et al. 2022. RSC Med Chem
Lapatinib Depiction based on curated SMILES O N NH F Cl S O O N H CH 3 O N Streptococcus Adherence Preclinical (in vivo) Manzer HS, et al. 2022. PLoS Pathog
5-Fluorouracil Depiction based on curated SMILES O HN O N H F Staphylococcus
Vibrio		 Biofilm
Biofilm		 Preclinical (in vivo)
Preclinical (in vivo)		 Sedlmayer F, et al. 2021. Nucleic Acids Res
Fursultiamin Depiction based on curated SMILES N NH 2 O S S OH CH 3 CH 3 O N N Vibrio HlyU Preclinical (in vivo) Imdad S, et al. 2018. Front Cell Infect Microbiol
4,6-dimethyl-N-[(Z)-1-pyridin-2-ylethylideneamino]pyrimidin-2-amine Depiction based on curated SMILES CH 3 N CH 3 CH 3 N HN N N Brucella VirB type IV secretion system Preclinical (in vivo) Paschos A, et al. 2011. Infect Immun
2-(4-tert-Butyl-phenoxymethyl)-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester Depiction based on curated SMILES CH 3 H 3 C H 3 C O CH 3 O HN N O O Brucella VirB type IV secretion system Preclinical (in vivo) Paschos A, et al. 2011. Infect Immun
[6,7-bis(chloranyl)-3-phosphono-quinoxalin-2-yl]phosphonic acid Depiction based on curated SMILES OH OH O P OH OH O P N N Cl Cl Bacillus
Clostridium		 Collagenase
Collagenase		 Preclinical (in vitro)
Preclinical (in vitro)		 Alhayek A, et al. 2022. J Med Chem
[6-(4-chlorophenyl)-3-phosphonoquinoxalin-2-yl]phosphonic acid Depiction based on curated SMILES N Cl OH OH O P OH OH O P N Bacillus
Clostridium		 Collagenase
Collagenase		 Preclinical (in vitro)
Preclinical (in vitro)		 Alhayek A, et al. 2022. J Med Chem
   


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