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Compound category: 2-arylbenzofuran flavonoids
(total 25 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
(-)-Hopeaphenol Depiction based on curated SMILES HO O OH HO HO OH OH O HO HO OH OH Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vivo)
Preclinical (in vivo)		 Zetterström CE, et al. 2013. PLoS One
(2R)-2-[[3-(1-benzofuran-2-yl)phenyl]sulfonylamino]-N-hydroxy-4-methylpentanamide Depiction based on curated SMILES OH HN O O H 3 C O O S N H H CH 3 Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
(2R,3R)-2-[[3-(1-benzofuran-2-yl)phenyl]sulfonylamino]-N-hydroxy-3-methylpentanamide Depiction based on curated SMILES HO N H O O CH 3 O O S HN H H 3 C H Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
(2S)-2-[[3-(1-benzofuran-2-yl)phenyl]sulfonylamino]-N-hydroxyhexanamide Depiction based on curated SMILES HO N H O O CH 3 O O S HN H Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
(2S,3S)-2-[[3-(1-benzofuran-2-yl)phenyl]sulfonylamino]-N-hydroxy-3-methylpentanamide Depiction based on curated SMILES OH N H O O H 3 C O O S N H H 3 C Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
3-(1-benzofuran-2-yl)-N-[(2R)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]benzamide Depiction based on curated SMILES HO NH O O H 3 C O N H H CH 3 Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
3-(1-benzofuran-2-yl)-N-[(2R,3R)-1-(hydroxyamino)-3-methyl-1-oxopentan-2-yl]benzamide Depiction based on curated SMILES HO NH O O H 3 C O N H H H 3 C H Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
3-(1-benzofuran-2-yl)-N-[(2S,3S)-1-(hydroxyamino)-3-methyl-1-oxopentan-2-yl]benzamide Depiction based on curated SMILES HO N H O O CH 3 O N H CH 3 Clostridium BoNT (Botulinum neurotoxin) Preclinical (in vitro) Thompson JC, et al. 2020. Bioorg Med Chem
I-A09 Depiction based on curated SMILES O N O HO HO O N HN O N N Mycobacterium Exoenzyme Preclinical (in vitro) Zhou B, et al. 2010. Proc Natl Acad Sci U S A
3-[1-[3-(1,3-benzothiazol-2-ylamino)-3-oxopropyl]triazol-4-yl]-6-hydroxy-2-phenyl-1-benzofuran-5-carboxylic acid Depiction based on curated SMILES O HO HO N N N H N S N O O Yersinia TTSS secreted effectors Preclinical (in vitro) Huang Z, et al. 2010. Chem Biol Drug Des
   


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